Abstract摘要
Background: The
treatment of articular cartilage defects is a therapeutic challenge for
orthopaedic surgeons. Furthermore, large osteochondral defects needs
restoration of the underlying bone for sufficient biomechanical characteristics
as well as the overlying cartilage.
背景：關(guān)節(jié)軟骨缺損的治療對骨外科來說是一項非常大的挑戰(zhàn)。此外，骨軟骨的再生需要軟骨下骨有足夠的類似于軟骨的生物學(xué)特性。
Case presentation: A symptomatic large osteochondral defect in the knee joint was restored using a composite of umbilical cord blood-derived mesenchymal stem cells (UCB-MSCs) 0.5 x 107/ml and 4% hyaluronic acid (HA) hydrogel. Significant improvements in pain and function of the knee joint were identified by the evaluation at 12 months after surgery. A hyaline-like cartilage completely filled the defect and was congruent with the surrounding normal cartilage as revealed by magnetic resonance imaging (MRI), a second-look arthroscopy and histological assessment. The improved clinical outcomes maintained until 5.5 years. MRI also showed the maintenance of the restored bony and cartilaginous tissues.
案例介紹：具有大面積膝關(guān)節(jié)軟骨缺損癥狀的病人使用人臍帶血來源間充質(zhì)干細(xì)胞（0.5×107細(xì)胞/ml）和玻璃酸鈉（4%）混合物進行治療。手術(shù)后12個月評估發(fā)現(xiàn)膝關(guān)節(jié)的功能和疼痛情況出現(xiàn)顯著的改善。磁共振（MRI）、二次關(guān)節(jié)鏡和組織學(xué)評估檢查發(fā)現(xiàn)透明樣軟骨完全填充到缺損部位并且和周圍正常軟骨融合到了一起。如此明顯的臨床療效一直持續(xù)了5.5年。
Conclusion: This case report suggests that the
composite of allogeneic UCB-MSCs and HA hydrogel can be considered a safe and
effective treatment option for large osteochondral defects of the knee.
結(jié)論：這份病例報告表明，人臍帶血來源間充質(zhì)干細(xì)胞和玻璃酸鈉混合物是一種安全、有效的治療膝關(guān)節(jié)軟骨大面積缺損的方法。
Keywords: Knee, Large osteochondral defect, Umbilical
cord blood, Mesenchymal stem cell, Hyaluronic acid
關(guān)鍵詞：膝、大面積軟骨缺損、臍帶血、間充質(zhì)干細(xì)胞、透明質(zhì)酸
附原文：
